Week Zero of the 2019 season gets underway on Saturday, before the FBS heavyweights take the field on Thursday.
The Denver Broncos have lost both of their preseason games and have been hampered by poor discipline, while the 49ers have already lost players to injuries.
Ole Gunnar Solskjaer's team travels to Wolverhampton looking to make it back-to-back wins in the first two games of the season.
Southeast, Japan and Asia-Pacific have already qualified for the semifinals, before inclement weather caused havoc.
Six games will be nationally broadcast in Week 3 of preseason, beginning with the Jacksonville Jaguars' trip to Miami on Thursday night.
Both the Saints and the Chargers lost their first preseason games and will be looking to bounce back on Sunday.
The two NFC rivals go head-to-head in Minneapolis on Sunday looking to make it two consecutive wins in preseason.
Atlanta takes on the Timbers on the back of a four-game winning streak and fresh from winning its first continental trophy.
Chelsea hosts Leicester City looking to bounce back from the opening day drubbing against Manchester United.
The two NFC rivals meet in Honolulu, Hawaii, on Saturday night as they look to fine-tune their preparations for the upcoming season.
The joint favorite to win Super Bowl LIV travels to Pittsburgh to play a Steelers team mourning the loss of wide receivers coach Darryl Drake.
The Western Conference rivals desperately need to find some form after winning just two of their last eight games combined.
The Indianapolis Colts are likely to be without Andrew Luck as they look to bounce back after losing to the Buffalo Bills last week.
The Premier League champions host Tottenham on Saturday afternoon hoping to make it two wins in two.
Liverpool travels to Southampton looking to make it two wins in two Premier League games after thrashing Norwich City last time out.
After a big overhaul in the summer, Real Madrid begins its league campaign against Celta Vigo on Saturday.
Arsenal hosts Burnley on Saturday, looking to win the opening two fixtures of a Premier League games for the first time since 2009.
After a summer of lavish spending, Barcelona begins its quest for a third consecutive La Liga title on Friday.
The Bears travel to New Jersey looking for a first preseason win, while the Giants look to make it two in two.
Defending champions Barcelona get the ball rolling on Friday when they take on Athletic Bilbao.
Justin Thomas and Jason Kokrak lead the BMW Championship by one shot after the first round at Medinah, Illinois.
Britain's Georgia Taylor-Brown and Jess Learmonth crossed the line together at an Olympic test event in Tokyo but were disqualified.
The Raiders and the Cardinals will both be looking for a second successive win when they meet in Arizona on Thursday.
The best youth players in world baseball will square off in Pennsylvania over the next 10 days from Thursday, August 15.
Woods has slipped to 38th in the FedEx Cup standings and needs a top-11 finish at the BMW Championship to qualify for the Tour Championship.
Rory McIlroy, Brooks Koepka and Patrick Reed will play alongside each other for the first two rounds in Medinah, Illinois.
World number one Brooks Koepka and Rory McIlroy are the joint-favorites ahead of the second event of the FedEx Cup playoffs.
Liverpool takes on Chelsea on Wednesday as Istanbul hosts the first All-English European Super Cup Final.
From Antonio Brown explaining his injury, to Jon Gruden's concerns over the receiver's return date, episode two provided plenty of talking points
The second episode of 'Hard Knocks' shed light on Antonio Brown's foot injury but not on his return date.